The contribution of TNF-α in the amygdala to anxiety in mice with persistent inflammatory pain.

@article{Chen2013TheCO,
  title={The contribution of TNF-α in the amygdala to anxiety in mice with persistent inflammatory pain.},
  author={Jun Chen and Yang Song and Jing Yang and Yong Zhang and Peng Zhao and Xue-jun Zhu and Hai-chuan Su},
  journal={Neuroscience letters},
  year={2013},
  volume={541},
  pages={275-80}
}
Tumor necrosis factor alpha (TNF-α) is known for its role in inflammation and pain, which are strongly associated with mood disorders such as anxiety and depression. The amygdala is a forebrain structure that modulates anxiety. However, little is known about the role of TNF-α in the development of anxiety in animals with chronic pain. In the present study, we examined TNF-α expression in the basolateral amygdala (BLA) following injection of complete Freund's adjuvant (CFA) into the hind paw of… CONTINUE READING
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