The contribution of L3T4+ T cells to lymphoproliferation and autoantibody production in MRL-lpr/lpr mice

@article{Santoro1988TheCO,
  title={The contribution of L3T4+ T cells to lymphoproliferation and autoantibody production in MRL-lpr/lpr mice},
  author={Thomas Santoro and Joseph P Portanova and Brian L. Kotzin},
  journal={The Journal of Experimental Medicine},
  year={1988},
  volume={167},
  pages={1713 - 1718}
}
The current study examines the role of the L3T4 T cell subset in the development of lupus-like autoimmunity and lymphoproliferation in lpr-bearing mice. Chronic treatment of MRL-lpr/lpr mice with anti-L3T4 antibody beginning at 4 wk old was found to markedly decrease the production of IgG anti-DNA and antihistone antibodies, while having no effect on IgM autoantibodies. A dramatic reduction in splenomegaly and lymphadenopathy was also observed coincident with a decrease in the percentage and… CONTINUE READING

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