The contribution of 1H-magnetic resonance spectroscopy in defining the pathophysiology of multiple sclerosis

@article{Simone1999TheCO,
  title={The contribution of 1H-magnetic resonance spectroscopy in defining the pathophysiology of multiple sclerosis},
  author={Isabella Laura Simone and Carla Tortorella and Francesco Federico},
  journal={The Italian Journal of Neurological Sciences},
  year={1999},
  volume={20},
  pages={S241-S245}
}
Proton magnetic resonance spectroscopy (1H-MRS) is considered a suitable investigation technique for obtaining in vivo information on pathological changes in multiple sclerosis (MS) brain. The main betabolites identified are choline-containing compounds, creatine, N-acetylaspartate (NAA), lactate, mobile lipids, myo-inositol, glutamate and glutamine. Proton spectra may be acquired from localized volumes of interest on single MS lesions or from the entire brain by 1H-MRS imaging. An increase of… CONTINUE READING

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The New England journal of medicine • 1998
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