The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis.

@article{Ram1999TheCM,
  title={The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis.},
  author={S. Ram and F. Mackinnon and S. Gulati and D. McQuillen and U. Vogel and M. Frosch and C. Elkins and H. Guttormsen and L. Wetzler and M. Oppermann and M. Pangburn and P. Rice},
  journal={Molecular immunology},
  year={1999},
  volume={36 13-14},
  pages={
          915-28
        }
}
Neisseria gonorrhoeae and Neisseria meningitidis have evolved intricate mechanisms to evade complement-mediated killing. Sialylation of gonococcal lipooligosaccharide (LOS) results in conversion of previously serum sensitive strains to unstable serum resistance, which is mediated by factor H binding. Porin (Por) is also instrumental in mediating stable serum resistance in gonococci. The 5th loop of certain gonococcal PorlAs binds factor H, which efficiently inactivates C3b to iC3b. Factor H… Expand
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