The contractile effect of bombesin on the rat isolated urinary bladder.

@article{AbdelHakim1981TheCE,
  title={The contractile effect of bombesin on the rat isolated urinary bladder.},
  author={A M Abdel-Hakim and Frank Rioux and Mostafa M. Elhilali},
  journal={European journal of pharmacology},
  year={1981},
  volume={70 2},
  pages={167-73}
}
We have investigated and compared the myotropic effects of bombesin (BB) and carbachol (C) in the rat isolated urinary bladder. BB (0.5 x 10(-9) to 0.5 x 10(-5) M) and C (2.7 x 10(-8) to 5.4 x 10(-5) M) were found to produce dose-dependent increases of the basal tone of the rat detrusor muscle. The maximal contraction produced by C was about 4 times greater than that elicited by BB or substance P (SP). However, the threshold concentrations of BB and SP required to stimulate the detrusor muscle… CONTINUE READING