The contractile behaviour of EGTA- and detergent-treated heart muscle

@article{Miller1985TheCB,
  title={The contractile behaviour of EGTA- and detergent-treated heart muscle},
  author={D J Miller and Godfrey L. Smith},
  journal={Journal of Muscle Research & Cell Motility},
  year={1985},
  volume={6},
  pages={541-567}
}
Tension responses of rat ventricular trabeculae subjected to successive ‘treatment’ with EGTA and Triton X-100 are described in order to investigate the effects of chemical ‘skinning’ techniques. In some preparations the alkaloid saponin was also used before Triton. Ultrastructural evidence is cited that the ‘EGTA-treatment’ fails to render cells ‘hyperpermeable’, i.e. freely permeable to small ions, whereas both saponin and Triton do so. In this paper we show that contractile responses like… CONTINUE READING