The continuity of protein structure space is an intrinsic property of proteins.

@article{Skolnick2009TheCO,
  title={The continuity of protein structure space is an intrinsic property of proteins.},
  author={Jeffrey Skolnick and Adrian K. Arakaki and Seung Yup Lee and Michal Brylinski},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 37},
  pages={15690-5}
}
The classical view of the space of protein structures is that it is populated by a discrete set of protein folds. For proteins up to 200 residues long, by using structural alignments and building upon ideas of the completeness and continuity of structure space, we show that nearly any structure is significantly related to any other using a transitive set of no more than 7 intermediate structurally related proteins. This result holds for all structures in the Protein Data Bank, even when… CONTINUE READING

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