The contact system contributes to hypotension but not disseminated intravascular coagulation in lethal bacteremia. In vivo use of a monoclonal anti-factor XII antibody to block contact activation in baboons.

@article{Pixley1993TheCS,
  title={The contact system contributes to hypotension but not disseminated intravascular coagulation in lethal bacteremia. In vivo use of a monoclonal anti-factor XII antibody to block contact activation in baboons.},
  author={Robin A. Pixley and R A de la Cadena and James D. Page and Nathan Kaufman and E G Wyshock and Alvin Chang and Fletcher B. Taylor and Robert W. Colman},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={91 1},
  pages={61-8}
}
The hypotension and disseminated intravascular coagulation (DIC) in bacteremia is thought to be mediated by the combined actions of cytokines, prostaglandins, and complement. The contact system, via the release of bradykinin and the activation of Factor XI, has been postulated to be contributing to the observed hypotension and DIC. Using a mAb to Factor XII (C6B7), we blocked the activation of the contact system in an established experimental baboon model in which Escherichia coli was infused… CONTINUE READING