The contact region between three domains of the extracellular loop of ASIC1a is critical for channel function.

@article{Bargeton2010TheCR,
  title={The contact region between three domains of the extracellular loop of ASIC1a is critical for channel function.},
  author={Beno{\^i}te Bargeton and Stephan Kellenberger},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 18},
  pages={13816-26}
}
Acid-sensing ion channels are members of the epithelial Na(+) channel/degenerin family. They are neuronal nonvoltage-gated Na(+) channels that are activated by extracellular acidification. In this study, we investigated the role of a highly conserved region of the extracellular part of ASIC1a that forms the contact between the finger domain, the adjacent beta-ball, and the upper palm domain in ASIC1a. The finger domain contributes to the pH-dependent gating and is linked via this contact zone… CONTINUE READING

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