The construction and evaluation of SIV/HIV chimeras that express the envelope of European HIV type 1 isolates.

@article{Ranjbar1997TheCA,
  title={The construction and evaluation of SIV/HIV chimeras that express the envelope of European HIV type 1 isolates.},
  author={Shayan Ranjbar and Steven Norman Jones and E. J. Stott and N. W. Almond},
  journal={AIDS research and human retroviruses},
  year={1997},
  volume={13 9},
  pages={797-800}
}
The molecular construction of SIV/HIV-1 chimeric viruses (or SHIVs), provides a means of infecting macaques with immunodeficiency viruses that express the envelope protein of HIV-1. However, to date, most SHIVs produced express the envelope of isolates of HIV-1 that have been passaged repeatedly in T cell lines. We have taken SHIV-4 and replaced an NheI-AvrII fragment that encompasses the gp120 region and the extracellular portion of gp41 with the equivalent region of two European isolates of… CONTINUE READING

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