The constitutive and stress inducible forms of hsp 70 exhibit functional similarities and interact with one another in an ATP- dependent fashion

@article{Brown1993TheCA,
  title={The constitutive and stress inducible forms of hsp 70 exhibit functional similarities and interact with one another in an ATP- dependent fashion},
  author={Christopher R. Brown and Robert L. Martin and William J. Hansen and Richard P Beckmann and William J. Welch},
  journal={The Journal of Cell Biology},
  year={1993},
  volume={120},
  pages={1101 - 1112}
}
Mammalian cells constitutively express a cytosolic and nuclear form of heat shock protein (hsp) 70, referred to here as hsp 73. In response to heat shock or other metabolic insults, increased expression of another cytosolic and nuclear form of hsp 70, hsp 72, is observed. The constitutively expressed hsp 73, and stress-inducible hsp 72, are highly related proteins. Still unclear, however, is exactly why most eukaryotic cells, in contrast to prokaryotic cells, express a novel form of hsp 70 (i.e… CONTINUE READING