The consolidation of neuroleptic therapy: Janssen, the discovery of haloperidol and its introduction into clinical practice

@article{LpezMuoz2009TheCO,
  title={The consolidation of neuroleptic therapy: Janssen, the discovery of haloperidol and its introduction into clinical practice},
  author={F. L{\'o}pez-Mu{\~n}oz and C. {\'A}lamo},
  journal={Brain Research Bulletin},
  year={2009},
  volume={79},
  pages={130-141}
}
The discovery of haloperidol at the end of the 1950s constitutes one of the greatest advances of 20th century psychiatry. This antipsychotic drug has their origin in the research process of central analgesic molecules derived from pethidine and methadone, carried out by the Belgian company Janssen Phamaceutica. After the synthesis of phenoperidine, numerous analogues of this compound were studied, and chemists at Janssen took the decision to substitute the propiophenone group for a… Expand
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