The consolidation of neuroleptic therapy: Janssen, the discovery of haloperidol and its introduction into clinical practice

@article{LpezMuoz2009TheCO,
  title={The consolidation of neuroleptic therapy: Janssen, the discovery of haloperidol and its introduction into clinical practice},
  author={Francisco Javier L{\'o}pez-Mu{\~n}oz and Cecilio {\'A}lamo},
  journal={Brain Research Bulletin},
  year={2009},
  volume={79},
  pages={130-141}
}
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A straightforward relationship between administered dose, plasma or serum concentration, clinical outcome, or adverse effects is often lacking, so extensive research in this field is still mandatory.
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The subsequent clinical studies, including those of the prestigious French school of Sainte-Anne hospital, confirmed that haloperidol belongs to the pharmacological family of neuroleptics, as it was defined by J. Delay and P. Deniker in 1955.
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The authors describe 40 years of antipsychotic drug research with Dr. Paul Janssen, which they have witnessed for a large part from first hand experience and discuss the lack of inhibition as a common trait of stereotyped behaviour in schizophrenia and the means of determining it by means of a computerized version of Bente's button press test.
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The results leave no doubt that the injection of reserpine caused a loss in hypothalamic noradrenaline; the loss was very severe in the young kittens, less so in the adult animals and was at least as great as that produced by large doses of morphine.
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