The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans.

@article{Moffat2014TheCT,
  title={The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans.},
  author={Laura L Moffat and Ryan E. Robinson and Anastasia Bakoulis and Scott G. Clark},
  journal={Development},
  year={2014},
  volume={141 3},
  pages={
          617-28
        }
}
Wnts control a wide range of essential developmental processes, including cell fate specification, axon guidance and anteroposterior neuronal polarization. We identified a conserved transmembrane RING finger protein, PLR-1, that governs the response to Wnts by lowering cell-surface levels of the Frizzled family of Wnt receptors in Caenorhabditis elegans. Loss of PLR-1 activity in the neuron AVG causes its anteroposterior polarity to be symmetric or reversed because signaling by the Wnts CWN-1… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

Keeping Wnt signalosome in check by vesicular traffic.

  • Journal of cellular physiology
  • 2015
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Endocytic control of signaling at the plasma membrane.

  • Current opinion in cell biology
  • 2016
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 56 REFERENCES

The structure of the ventral nerve cord of Caenorhabditis elegans.

  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1976
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL