The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast.

@article{Biggins1999TheCP,
  title={The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast.},
  author={Scott W. Biggins and Fedor F. Severin and Needhi Bhalla and Ingrid Sassoon and Anthony A. Hyman and Andrew W. Murray},
  journal={Genes & development},
  year={1999},
  volume={13 5},
  pages={532-44}
}
Chromosome segregation depends on kinetochores, the structures that mediate chromosome attachment to the mitotic spindle. We isolated mutants in IPL1, which encodes a protein kinase, in a screen for budding yeast mutants that have defects in sister chromatid separation and segregation. Cytological tests show that ipl1 mutants can separate sister chromatids but are defective in chromosome segregation. Kinetochores assembled in extracts from ipl1 mutants show altered binding to microtubules… CONTINUE READING
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