The conserved core of a human SIR2 homologue functions in yeast silencing.

  title={The conserved core of a human SIR2 homologue functions in yeast silencing.},
  author={J M Sherman and Edwin M. Stone and Lisa L Freeman-Cook and Carrie Baker Brachmann and Jef D. Boeke and Lorraine Pillus},
  journal={Molecular biology of the cell},
  volume={10 9},
Silencing is a universal form of transcriptional regulation in which regions of the genome are reversibly inactivated by changes in chromatin structure. Sir2 (Silent Information Regulator) protein is unique among the silencing factors in Saccharomyces cerevisiae because it silences the rDNA as well as the silent mating-type loci and telomeres. Discovery of a gene family of Homologues of Sir Two (HSTs) in organisms from bacteria to humans suggests that SIR2's silencing mechanism might be… CONTINUE READING

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