The conserved clag multigene family of malaria parasites: essential roles in host-pathogen interaction.

@article{Gupta2015TheCC,
  title={The conserved clag multigene family of malaria parasites: essential roles in host-pathogen interaction.},
  author={Ankit Gupta and Girija 7 Thiruvengadam and Sanjay A Desai},
  journal={Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy},
  year={2015},
  volume={18},
  pages={
          47-54
        }
}
The clag multigene family is strictly conserved in malaria parasites, but absent from neighboring genera of protozoan parasites. Early research pointed to roles in merozoite invasion and infected cell cytoadherence, but more recent studies have implicated channel-mediated uptake of ions and nutrients from host plasma. Here, we review the current understanding of this gene family, which appears to be central to host-parasite interactions and an important therapeutic target. 
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