The conserved Pkh–Ypk kinase cascade is required for endocytosis in yeast

@article{deHart2002TheCP,
  title={The conserved Pkh–Ypk kinase cascade is required for endocytosis in yeast},
  author={Amy K.A. deHart and Joshua D. Schnell and Damian A. Allen and Linda Hicke},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={156},
  pages={241 - 248}
}
Internalization of activated signaling receptors by endocytosis is one way cells downregulate extracellular signals. Like many signaling receptors, the yeast alpha-factor pheromone receptor is downregulated by hyperphosphorylation, ubiquitination, and subsequent internalization and degradation in the lysosome-like vacuole. In a screen to detect proteins involved in ubiquitin-dependent receptor internalization, we identified the sphingoid base-regulated serine-threonine kinase Ypk1. Ypk1 is a… CONTINUE READING

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