The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5.

Abstract

Kinesin superfamily motor proteins contain a structurally conserved loop near the ATP binding site, termed L5. The function of L5 is unknown, although several drug inhibitors of the mitotic kinesin Eg5 bind to L5. We used electron paramagnetic resonance spectroscopy (EPR) to investigate the function of L5 in Eg5. We site-specifically attached EPR probes to… (More)
DOI: 10.1016/j.bpj.2010.03.014

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