The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2.

@article{Zimmer2010TheCM,
  title={The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2.},
  author={Michael F. Zimmer and Justin Meredith Lamb and Benjamin L. Ebert and Mary Jo Lynch and Christopher Neil and Emmett Schmidt and Todd R. Golub and Othon Iliopoulos},
  journal={Cancer research},
  year={2010},
  volume={70 8},
  pages={
          3071-9
        }
}
Hypoxia-inducible factors 1 and 2 (HIF1 and HIF2) are heterodimeric transcription factors consisting of alpha regulatory subunits and a constitutively expressed beta subunit. The expression of alpha regulatory subunits is promoted by hypoxia, cancer-associated mutations, and inflammatory cytokines. Thus, HIF1 and HIF2 provide a molecular link between cancer and inflammation. We have recently identified novel small molecules that selectively inhibit translation of the HIF2a message and thereby… CONTINUE READING
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