The connection of β-catenin and phenobarbital in murine hepatocarcinogenesis: a critical discussion of Awuah et al., PLoS ONE 7(6):e39771, 2012

@article{Braeuning2012TheCO,
  title={The connection of β-catenin and phenobarbital in murine hepatocarcinogenesis: a critical discussion of Awuah et al., PLoS ONE 7(6):e39771, 2012},
  author={Albert Braeuning},
  journal={Archives of Toxicology},
  year={2012},
  volume={87},
  pages={401-402}
}
Phenobarbital (PB) is frequently used as a promoter of rodent liver tumors. The mechanisms by which PB exerts its tumorpromoting activity are still not fully understood, but the constitutive androstane receptor (CAR) and b-catenin seem to be essentially involved: Experiments with Car knockout (KO) mice have proven that the presence of CAR is mandatory for PB-mediated tumor promotion (Yamamoto et al. 2004). In mice, PB selects for the outgrowth of hepatocellular tumors with activating mutations… CONTINUE READING
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