The connection between the steady state (Vss) and terminal (Vbeta) volumes of distribution in linear pharmacokinetics and the general proof that Vbeta >/= Vss.

Abstract

The steady state and terminal (area) volumes of distribution are important pharmacokinetic parameters defined as the ratio of the total quantity of drug in the body, A(b)(t), to drug plasma concentration C(p)(t) at steady state and the terminal phase of drug elimination, respectively. The general equations for the approach of C(p)(t), A(b)(t) and the… (More)

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