The conjugation of an AQP1-directed immunotoxin in the study of site-directed therapy within the CNS

@article{Surash2010TheCO,
  title={The conjugation of an AQP1-directed immunotoxin in the study of site-directed therapy within the CNS},
  author={Surash Surash and P{\'e}ter N{\'e}meth and Aruna K Chakrabarty and Paul Chumas},
  journal={Child's Nervous System},
  year={2010},
  volume={27},
  pages={811-818}
}
PurposeThe water channel, aquaporin (AQP)1, is highly specific to the choroid plexus (CP) epithelium within the brain. It is therefore a potential target through which therapeutic agents could be selectively directed to the CP. Here we describe the conjugation of a monoclonal antibody (mAb), raised against an extra-cellular domain of AQP1, to the A chain of ricin (RCA). This reagent should allow study of a highly specific chemical lesion of the CP.MethodsA published method was used to couple… CONTINUE READING
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