The conformational behaviour of phosphatidylinositol.

  title={The conformational behaviour of phosphatidylinositol.},
  author={Richard J Bushby and Stephen J Byard and Philip M Hansbro and David G Reid},
  journal={Biochimica et biophysica acta},
  volume={1044 2},
The temperature dependence of the 1H-NMR spectrum of phosphatidylinositol (PI) in d6-dimethylsulphoxide (DMSO) shows that the hydroxy groups at C2 and at C6 of the inositol ring are internally hydrogen-bonded. This probably implies a trans/gauche conformation for the phosphate/inositol linkage. The presence of a trans phosphate-alkyl-oxygen bond is confirmed by 31P-NMR studies. If the conformation of PI in membranes is the same as that in DMSO solution, this implies that the inositol ring… CONTINUE READING