The conformation of new tetrahydropyrimidine derivatives in solution and in the crystal.

@article{Inbar1993TheCO,
  title={The conformation of new tetrahydropyrimidine derivatives in solution and in the crystal.},
  author={L Inbar and Felix Frolow and Aviva Lapidot},
  journal={European journal of biochemistry},
  year={1993},
  volume={214 3},
  pages={897-906}
}
We have recently identified by NMR techniques two new tetrahydropyrimidine derivatives, 2-methyl-4-carboxy-5-hydroxy-3,4,5,6-tetrahydropyrimidine [THP(A)] and 2-methyl-4-carboxy-3,4,5,6-tetrahydropyrimidine [THP(B)], which accumulated in actinomycin D producing Streptomyces parvulus. Their relatively high intracellular concentrations during actinomycin D synthesis and identity of the time of onset of their synthesis with that of actinomycin D synthesis leads us to suggest that they may function… CONTINUE READING

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