The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells

@inproceedings{Zheng2010TheCC,
  title={The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells},
  author={Yihu Zheng and Mengtao Zhou and Aifang Ye and Qiu Gen Li and Yongheng Bai and Qiyu Zhang},
  booktitle={World journal of surgical oncology},
  year={2010}
}
BACKGROUND Arsenic trioxide has been established as a first-line agent for treating acute promyelocytic leukemia. Experimental data suggest that arsenic trioxide also can have a potential use as chemotherapeutic agent for other malignancies. The precise mechanisms of action of arsenic trioxide have though not been elucidated. As the role of Bcl-2 in arsenic trioxide-mediated cell apoptosis and conformation change of Bcl-2 in response to arsenic trioxide treatment has not been studied. The aim… CONTINUE READING
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