The confidence interval of allelic odds ratios under the Hardy-Weinberg disequilibrium

Abstract

AbstractIn single nucleotide polymorphism (SNP) data analysis, the allelic odds ratio and its confidence interval (CI) are usually used to evaluate the association between disease and alleles at each SNP. The usual formula for calculating the CI of the allelic odds ratio based on the Hardy-Weinberg equilibrium (HWE) may, however, lead to errors beyond the… (More)
DOI: 10.1007/s10038-006-0020-6

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