The conduct of in vitro studies to address time-dependent inhibition of drug-metabolizing enzymes: a perspective of the pharmaceutical research and manufacturers of America.

@article{Grimm2009TheCO,
  title={The conduct of in vitro studies to address time-dependent inhibition of drug-metabolizing enzymes: a perspective of the pharmaceutical research and manufacturers of America.},
  author={Scott W. Grimm and Heidi J. Einolf and Steven D Hall and Kan He and Heng-Keang Lim and K J Ling and Chuang Lu and Amin A. Nomeir and Eleanore Seibert and Konstantine W. Skordos and George R. Tonn and Robert D. Van Horn and R. W. Y. Wang and Y. Nancy Wong and Tian J. Yang and R Scott Obach},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2009},
  volume={37 7},
  pages={1355-70}
}
Time-dependent inhibition (TDI) of cytochrome P450 (P450) enzymes caused by new molecular entities (NMEs) is of concern because such compounds can be responsible for clinically relevant drug-drug interactions (DDI). Although the biochemistry underlying mechanism-based inactivation (MBI) of P450 enzymes has been generally understood for several years, significant advances have been made only in the past few years regarding how in vitro time-dependent inhibition data can be used to understand and… CONTINUE READING
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References

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Mechanism-based enzyme inactivation. Contemporary enzyme kinetics and mechanism, 2nd edition

  • RB Silverman
  • 1988
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7 Excerpts

A modified inhibition assay to identify CYP3A4 mechanism-based inhibitors

  • P Li, C Lu, JS Daniels, J Labutti, GT Miwa, LS Gan
  • Drug Metab Rev (Supplement
  • 2005
Highly Influential
3 Excerpts

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