The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation.

@article{Molle2006TheCA,
  title={The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation.},
  author={Virginie Molle and Alistair K. Brown and Gurdyal S Besra and Alain J. Cozzone and Laurent Kremer},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 40},
  pages={30094-103}
}
Phosphorylation of proteins by Ser/Thr protein kinases (STPKs) has recently become of major physiological importance because of its possible involvement in virulence of bacterial pathogens. Although Mycobacterium tuberculosis has eleven STPKs, the nature and function of the substrates of these enzymes remain largely unknown. In this work, we have identified for the first time STPK substrates in M. tuberculosis forming part of the type II fatty acid synthase (FAS-II) system involved in mycolic… CONTINUE READING