The condensin complex is required for proper spindle assembly and chromosome segregation in Xenopus egg extracts

@article{Wignall2003TheCC,
  title={The condensin complex is required for proper spindle assembly and chromosome segregation in Xenopus egg extracts},
  author={Sarah M Wignall and Ren{\'e}e Deehan and Thomas J Maresca and Rebecca Heald},
  journal={The Journal of Cell Biology},
  year={2003},
  volume={161},
  pages={1041 - 1051}
}
Chromosome condensation is required for the physical resolution and segregation of sister chromatids during cell division, but the precise role of higher order chromatin structure in mitotic chromosome functions is unclear. Here, we address the role of the major condensation machinery, the condensin complex, in spindle assembly and function in Xenopus laevis egg extracts. Immunodepletion of condensin inhibited microtubule growth and organization around chromosomes, reducing the percentage of… CONTINUE READING
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