The condensin I subunit Barren/CAP-H is essential for the structural integrity of centromeric heterochromatin during mitosis.

@article{Oliveira2005TheCI,
  title={The condensin I subunit Barren/CAP-H is essential for the structural integrity of centromeric heterochromatin during mitosis.},
  author={Raquel Araujo de Oliveira and Paula Almeida Coelho and Claudio E Sunkel},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 20},
  pages={8971-84}
}
During cell division, chromatin undergoes structural changes essential to ensure faithful segregation of the genome. Condensins, abundant components of mitotic chromosomes, are known to form two different complexes, condensins I and II. To further examine the role of condensin I in chromosome structure and in particular in centromere organization, we depleted from S2 cells the Drosophila CAP-H homologue Barren, a subunit exclusively associated with condensin I. In the absence of Barren/CAP-H… CONTINUE READING

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