The concomitant coronary vasodilator and positive inotropic actions of the nitroxyl donor Angeli's salt in the intact rat heart: contribution of soluble guanylyl cyclase-dependent and -independent mechanisms.

@article{Chin2014TheCC,
  title={The concomitant coronary vasodilator and positive inotropic actions of the nitroxyl donor Angeli's salt in the intact rat heart: contribution of soluble guanylyl cyclase-dependent and -independent mechanisms.},
  author={Kai Yee Chin and Chengxue Qin and Nga Cao and Barbara K. Kemp-Harper and Owen L Woodman and Rebecca H. Ritchie},
  journal={British journal of pharmacology},
  year={2014},
  volume={171 7},
  pages={1722-34}
}
BACKGROUND AND PURPOSE The NO redox sibling nitroxyl (HNO) elicits soluble guanylyl cyclase (sGC)-dependent vasodilatation. HNO has high reactivity with thiols, which is attributed with HNO-enhanced left ventricular (LV) function. Here, we tested the hypothesis that the concomitant vasodilatation and inotropic actions induced by a HNO donor, Angeli's salt (sodium trioxodinitrate), were sGC-dependent and sGC-independent respectively. EXPERIMENTAL APPROACH Haemodynamic responses to Angeli's… CONTINUE READING