The concept of translocational regulation

@article{Hegde2008TheCO,
  title={The concept of translocational regulation},
  author={Ramanujan S Hegde and S Kang},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={182},
  pages={225 - 232}
}
Biological processes are regulated to provide cells with exquisite adaptability to changing environmental conditions and cellular demands. The mechanisms regulating secretory and membrane protein translocation into the endoplasmic reticulum (ER) are unknown. A conceptual framework for translocational regulation is proposed based on our current mechanistic understanding of ER protein translocation and general principles of regulatory control.