The concept of coupling blood flow to brain function: revision required?

  title={The concept of coupling blood flow to brain function: revision required?},
  author={Hans Christensen Lou and L. Edvinsson and Eric T Mackenzie},
  journal={Annals of neurology},
  volume={22 3},
A tight coupling exists between brain function and cerebral perfusion in most situations. The Roy and Sherrington hypothesis has been widely accepted to account for the phenomenon: increased neuronal metabolic activity will give rise to the accumulation of vasoactive catabolites, which decrease vascular resistance and thereby increase blood flow until normal homeostasis is reestablished. However, the hypothesis does not account for the disproportionate increase in flow that occurs in a number… CONTINUE READING

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