The concentration of Nuf, a Rab11 effector, at the microtubule-organizing center is cell cycle regulated, dynein-dependent, and coincides with furrow formation.

@article{Riggs2007TheCO,
  title={The concentration of Nuf, a Rab11 effector, at the microtubule-organizing center is cell cycle regulated, dynein-dependent, and coincides with furrow formation.},
  author={Blake Riggs and Barbara Fasulo and Anne Royou and Sarah E. Mische and Jian Cao and Thomas S Hays and William Sullivan},
  journal={Molecular biology of the cell},
  year={2007},
  volume={18 9},
  pages={
          3313-22
        }
}
Animal cytokinesis relies on membrane addition as well as acto-myosin-based constriction. Recycling endosome (RE)-derived vesicles are a key source of this membrane. Rab11, a small GTPase associated with the RE and involved in vesicle targeting, is required for elongation of the cytokinetic furrow. In the early Drosophila embryo, Nuclear-fallout (Nuf), a Rab11 effector, promotes vesicle-mediated membrane delivery and actin organization at the invaginating furrow. Although Rab11 maintains a… CONTINUE READING
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