The concentration dependence of active potassium transport in the human red blood cell.

@article{Sachs1967TheCD,
  title={The concentration dependence of active potassium transport in the human red blood cell.},
  author={John R. Sachs and Louis G. Welt},
  journal={The Journal of clinical investigation},
  year={1967},
  volume={46 1},
  pages={
          65-76
        }
}
The relation between the active potassium influx in the human red blood cell and the extracellular potassium concentration does not appear to be consistent with the Michaelis-Menten model, but is adequately described by a model in which two potassium ions are required simultaneously at some site or sites in the transport mechanism before transport occurs. The same type of relation appears to exist between that portion of the sodium outflux that requires the presence of extracellular potassium… 
View on PubMed
jci.org
189 Citations
Highly Influential Citations
5
Background Citations
17
Methods Citations
15
Results Citations
2

189 Citations

Citation Type

Citation Type

Concentration dependence of active potassium transport in the human red blood cell in the presence of inhibitors.
TLDR
The kinetic behavior of the active potassium influx in the presence of the inhibitors strophanthidin and ethacrynic acid is consistent with a model in which the binding of potassium at one of the potassium-sensitive sites in the transport system reduces the affinity of the system for the drug.
Competitive effects of some cations on active potassium transport in the human red blood cell.
  • J. R. Sachs
  • Biology
    The Journal of clinical investigation
  • 1967
TLDR
The effect of some cations on the active potassium transport system of the human red blood cell has been investigated, and the affinity of the alkali metal cations for the sites appears to be explicable in terms of their physical characteristics.
Stimulation of the Sodium Pump in the Red Blood Cell by Lithium and Potassium
TLDR
This stimulation of the sodium pump by extracellular lithium may explain observations of a low intracellular sodium concentration under such conditions and may be relevant to the prophylactic action of lithium salts in manic-depressive disease.
Affinities or Apparent Affinities of the Transport Adenosine Triphosphatase System
TLDR
C Caldwell's (1968) Physiological Review model is discussed with particular reference to the observed kinetics of sodium: sodium exchange in red cells, and the interactions of potassium ions and ATP on transport ATPase activity are discussed.
Adenosine triphosphatase and active cation transport in red blood cell membranes.
TLDR
A membrane-associated enzyme, adenosine triphosphatase activated by Na and K (Na,K-ATPase), appears to be identical with the Na-K pump, and the evidence includes similar kinetic properties and responses to cardiac glycosides of the pump and Na,-K- ATPase.
Mechanistic implications of the potassium‐potassium exchange carried out by the sodium‐potassium pump.
TLDR
The results seem to require that the enzyme species which carries out the exchange is both phosphorylated and combined with ATP, which would suggest that the K‐K exchange is part of a ping‐pong reaction mechanism.
Na+ and K+ Transport in Human and Rat Erythrocytes: Features Complicating the Interpretation of Data
TLDR
It is an open question whether the transport phenomena susceptible to full or partial inhibition by loop diuretics (such as furosemide, piretanide and bumetanide) represent different modes of operation of one and the same system or are mediated by two different transport molecules.
Ouabain Binding and Cation Transport in Human Erythrocytes
TLDR
Findings indicate that the effects of these cations on ouabain binding reflect alterations in the rate of association of ouABain molecules with the erythrocyte membrane.
Active Cation Transport in Human Red Cells
TLDR
This paper begins with a brief analysis of the concept of active transport, in order to place the main subject, the ATP-dependent translocation of Na+, K+ and Ca++, in proper context.
Na and K Transport in Red Blood Cells
TLDR
It is hoped that the considerations of basic principles in one cell type will emphasize those features common to all cell types rather than those differences which distinguish one cell types from another.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 25 REFERENCES
The linkage of sodium, potassium, and ammonium active transport across the human erythrocyte membrane.
Sodium and potassium movements in human red cells
  • I. Glynn
  • Biology
    The Journal of physiology
  • 1956
TLDR
In the present experiments 24Na and 42K have been used to study the movements of sodium and potassium across the red cell membrane under a variety of experimental conditions to investigate the existence of a link between the active uptake of potassium and the active extrusion of sodium.
Regulation of Cell Volume by Active Cation Transport in High and Low Potassium Sheep Red Cells
TLDR
Both HK and LK sheep red cells control their cation composition and volume in a manner consistent with the model cell, and both cell types show appreciable sodium exchange diffusion but this process is more rapid in the LK than in the HK cells.
Potassium movements in washed erythrocytes
  • T. I. Shaw
  • Biology, Environmental Science
    The Journal of physiology
  • 1955
TLDR
Results have been extended to cover a wider range of potassium concentrations using horse, ox and sheep red cells as experimental material and the relationship between potassium influx and efflux studied.
The connexion between active cation transport and metabolism in erythrocytes.
TLDR
It is concluded that the rate of energy production in glycolysis is partly controlled by the magnitude of active transport; the extent of this regulation is shown to vary from 25 to 75% of a basal rate that is independent of active Transport.
STOICHIOMETRY AND LOCALIZATION OF ADENOSINE TRIPHOSPHATE-DEPENDENT SODIUM AND POTASSIUM TRANSPORT IN THE ERYTHROCYTE.
The effect of external sodium concentration on the sodium fluxes in frog skeletal muscle
TLDR
This work investigated the effect on the Na efflux of substituting choline or lithium for the sodium in the external medium, and found that in both cases the efflux was promptly reduced by about half when the Sodium in the interfibre fluid was replaced by the foreign cation.
Cation control in human erythrocytes
TLDR
The present paper seeks to define the effects of plasma Na and K concentrations on the active output of Na more clearly and to distinguish between real and apparent cation movements in cells mixed with buffer solutions.
A comparison of potassium 42, rubidium 86, and cesium 134 as tracers of potassium in the study of cation metabolism of human erythrocytes in vitro.
TLDR
The results suggest that Rb 86, with its half-life of 19.5 days, may be useful under some circumstances as a tracer for potassium, at least from a qualitative point of view.
The Distinction by Means of Tracers Between Active Transport and Diffusion
Summary. 1) It is shown that for a free ion diffusing through a membrane the ratio between the flux in one direction and the simultaneous flux in the opposite direction is independent of the…
...
1
2
3
...