The computational worm: spatial orientation and its neuronal basis in C. elegans

@article{Lockery2011TheCW,
  title={The computational worm: spatial orientation and its neuronal basis in C. elegans
},
  author={Shawn R. Lockery},
  journal={Current Opinion in Neurobiology},
  year={2011},
  volume={21},
  pages={782-790}
}
  • S. Lockery
  • Published 1 October 2011
  • Biology, Psychology
  • Current Opinion in Neurobiology

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References

SHOWING 1-10 OF 80 REFERENCES
A Neural Network Model of Chemotaxis Predicts Functions of Synaptic Connections in the Nematode Caenorhabditis elegans
TLDR
Common patterns of connectivity between the model and biological networks suggest new functions for previously identified connections in the C. elegans nervous system, and it is shown that feedback regulates the latency between sensory input and behavior.
Circuit motifs for spatial orientation behaviors identified by neural network optimization.
TLDR
This study used an unbiased optimization algorithm to seek values of neuronal time constants, resting potentials, and synaptic strengths sufficient for each type of behavior and found many different hill-climbing and goal-seeking networks that performed equally well in the two tasks.
Evolution and Analysis of Minimal Neural Circuits for Klinotaxis in Caenorhabditis elegans
TLDR
A minimalistic neural network, comprised of an ON-OFF pair of chemosensory neurons and a pair of neck muscle motor neurons, is sufficient to generate realistic klinotaxis behavior, suggesting that the model may be operating according to principles similar to those of the biological network.
Temporal Activity Patterns in Thermosensory Neurons of Freely Moving Caenorhabditis elegans Encode Spatial Thermal Gradients
TLDR
It is shown that the worm is able, in principle, to evaluate and guide its own thermotactic behaviors with respect to ambient spatial thermal gradients by monitoring the activity of this single thermosensory neuron.
A Hub-and-Spoke Circuit Drives Pheromone Attraction and Social Behavior in C. elegans
TLDR
The coordination of social behaviours by RMG suggests an anatomical hub-and-spoke model for sensory integration in aggregation, and points to functions for related circuit motifs in the C. elegans wiring diagram.
Genetic analysis of crawling and swimming locomotory patterns in C. elegans
TLDR
It is shown that Caenorhabditis elegans switches between distinct forms of locomotion, or crawling versus swimming, when transitioning between solid and liquid environments.
Optogenetic analysis of synaptic transmission in the central nervous system of the nematode Caenorhabditis elegans.
TLDR
A model in which the energetic cost of escape behaviours in C. elegans is tuned to the intensity of the threat is proposed, and it is found that escape probability mirrors the time course of synaptic current in the command neuron.
A circuit for navigation in Caenorhabditis elegans.
TLDR
The roles of individual sensory neurons, interneurons, and motor neurons in exploratory behaviors under different conditions are dissected to suggest this circuit may represent a common substrate for multiple navigation behaviors.
A huband-spoke circuit drives pheromone attraction and social behaviour in C . elegans
TLDR
The coordination of social behaviours by RMG suggests an anatomical hub-and-spoke model for sensory integration in aggregation, and points to functions for related circuit motifs in the C. elegans wiring diagram.
...
1
2
3
4
5
...