The compulsion of chirality: toward an understanding of left-right asymmetry.

Abstract

Although it has long been clear that correct development of left–right (LR) asymmetry requires that tissues in the early embryo know whether they lie to the left or right of the midline, the molecular mechanisms that invariantly orient the LR axis have remained obscure. The recent demonstration that the iv (inverted viscerum) mutation in the mouse may be… (More)

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