The comprehensiveness of Medline and Embase computer searches

@article{Kleijnen2005TheCO,
  title={The comprehensiveness of Medline and Embase computer searches},
  author={Jos Kleijnen and Paul G. Knipschild},
  journal={Pharmaceutisch Weekblad},
  year={2005},
  volume={14},
  pages={316-320}
}
ObjectiveTo assess the comprehensiveness of Medline and Embase computer searches for controlled trials.DesignComparison of articles found after an exhaustive search of the literature with the yield of a Medline or Embase search. This was performed for controlled clinical trials on the efficacy of three interventions: homoeopathy, ascorbic acid for common cold, and ginkgo biloba for intermittent claudication and cerebral insufficiency. The number of controlled trials found by exhaustive search… 

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...

References

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Clinical trials of homoeopathy.

TLDR
The evidence of clinical trials is positive but not sufficient to draw definitive conclusions because most trials are of low methodological quality and because of the unknown role of publication bias, which indicates that there is a legitimate case for further evaluation of homoeopathy, but only by means of well performed trials.

[Treatment of irritable colon. A multicenter placebo-controlled double-blind study in general practice].

TLDR
The trial shows that it is possible to obtain objective results on the basis of the patients' judgment (rating scales with low information content) and both groups with active medication differed trivially but showed a marked superiority to the placebo group.

[Efficiency of homeopathic preparation combinations in sinusitis. Results of a randomized double blind study with general practitioners].

In a controlled randomized double-blind trial carried out by 47 physicians in private practice with totally 152 patients with sinusitis the therapeutic success of the following homeopathic drug

A double‐blind placebo‐controlled trial of tanakan in the treatment of idiopathic cognitive impairment in the elderly

TLDR
Improvements in mental efficiency were accompanied by a significant increase in the interest taken in everyday activities, and suggest that the drug might be helpful in treating the early stages of primary degenerative dementia.

A clinical trial of Gingkco Biloba Extract in patients with intermittent claudication.

TLDR
Gingkco Biloba Extract is a safe and effective method of improving walking distance and reducing pain severity in patients with intermittent claudication, although Doppler studies have failed to suggest any gross improvement in the perfusion of the ischaemic leg.

Vitamin C as a preventive medicine against common colds in children.

TLDR
Results seemed to indicate that the duration and severity of the cold were reduced while, on the other hand, the incidence remained unaltered or indeed increased, like previously published studies on children.

[Therapy of common cold with a homeopathic combination preparation in comparison with acetylsalicylic acid. A controlled, randomized double-blind study].

TLDR
No significant difference was determined with respect to changes in clinical findings, subjectively assessed complaints, or length of time the patients were unable to work on the 4th and 10th treatment days, thus the two preparations possess comparative effectiveness in the treatment of the common cold.

Vitamin C prophylaxis in a boarding school.

Abstract A double-blind study to evaluate vitamin C supplements for respiratory-Infection prophylaxis was conducted among 641 children at a Navajo boarding school over a 14-week period. Supplements

Trial of ascorbic acid in prevention of colds.

TLDR
In these studies, it is attempted by in-vitro experiments that exposure of cells to ascorbic acid increased their resistance to infection with viruses, and a protective effect in ftnmy»1« or man is attempted.