The composition of sleep-promoting factor isolated from human urine.

  title={The composition of sleep-promoting factor isolated from human urine.},
  author={James M. Krueger and John R. Pappenheimer and Manfred L. Karnovsky},
  journal={The Journal of biological chemistry},
  volume={257 4},
A sleep-promoting substance, Factor S, has been extracted and purified from large volumes of human urine. Urinary Factor S is a small glycopeptide; amino acid-amino sugar analyses of the purified material revealed a substance composed of glutamic acid, alanine, diaminopimelic acid, and muramic acid in molar ratios of 2:2:1:1. The active glycopeptide resembles bacterial peptidoglycans but the composition suggests that it is not simply of adventitious origin. Other reasons for this conclusion are… CONTINUE READING
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