The composition of pulmonary surfactant from diving mammals

@article{Miller2006TheCO,
  title={The composition of pulmonary surfactant from diving mammals},
  author={Natalie J. Miller and Anthony D. Postle and Sandra Orgeig and Grielof Koster and Christopher Brian Daniels},
  journal={Respiratory Physiology \& Neurobiology},
  year={2006},
  volume={152},
  pages={152-168}
}
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27 Citations
Background Citations
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27 Citations

The evolution of a physiological system: The pulmonary surfactant system in diving mammals
Phosphatidylcholine composition of pulmonary surfactant from terrestrial and marine diving mammals
Pulmonary surfactants and their role in pathophysiology of lung disorders.
TLDR
The biochemical, physiological, developmental and clinical aspects of pulmonary surfactant are presented in this article to understand the pathophysiological mechanisms of these diseases.
Environmental Selection Pressures Shaping the Pulmonary Surfactant System of Adult and Developing Lungs
TLDR
The major discoveries concerning how temperature, pressure and hypoxia have influenced the pulmonary surfactant system are summarised.
Effect of Lung Surfactant Protein SP-C and SP-C-Promoted Membrane Fragmentation on Cholesterol Dynamics.
Evolution, Development, and Function of the Pulmonary Surfactant System in Normal and Perturbed Environments.
TLDR
The evolutionary origin of the surfactant system, which likely predates lungs, is discussed and an analysis of the ontogeny of surfactants development among the vertebrates and the contribution of different regulatory mechanisms that control this development is presented.
Prenatal development of the pulmonary surfactant system and the influence of hypoxia
Recent Advances into Understanding Some Aspects of the Structure and Function of Mammalian and Avian Lungs*
TLDR
In the mammalian lung, dendritic cells of the pulmonary airways are powerful agents in engulfing deposited particles, and in birds, macrophages and erythrocytes are ardent phagocytizing cellular agents.
Respiratory function and mechanics in pinnipeds and cetaceans
TLDR
Improved understanding of respiratory physiology under these conditions will be better able to define the physiological constraints imposed on these animals, and how these limitations may affect the survival of marine mammals in a changing environment.
Intrinsic anti-inflammatory properties in the serum of two species of deep-diving seal
TLDR
The data suggest that seal serum possesses anti-inflammatory properties, which may protect deep divers from naturally occurring inflammatory challenges such as dive-induced hypoxia–reoxygenation and lung collapse.
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References

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Analysis of surfactant in bronchoalveolar lavage fluid obtained from nine pinnipeds and from pigs and humans found a higher concentration of phospholipid and relatively more fluidic phosphatidylcholine molecular species, perhaps to facilitate rapid spreading during alveolar reexpansion.
The surface activity of pulmonary surfactant from diving mammals
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Dipalmitoylphosphatidylcholine is not the major surfactant phospholipid species in all mammals.
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TLDR
High-resolution 31P NMR spectroscopy was used to analyze the phospholipid composition of mammalian pulmonary surfactant from two different sources and unequivocally demonstrate that a phosphocholine plasmalogen exists as a major secondary component in mammalian pulmonary Surfactant.
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