The composition of pulmonary surfactant from diving mammals

@article{Miller2006TheCO,
  title={The composition of pulmonary surfactant from diving mammals},
  author={N. Miller and A. Postle and S. Orgeig and G. Koster and C. Daniels},
  journal={Respiratory Physiology \& Neurobiology},
  year={2006},
  volume={152},
  pages={152-168}
}
Maintaining a functional pulmonary surfactant system at depth is critical for diving mammals to ensure that inspiration is possible upon re-emergence. The lipid and protein composition of lavage extracts from three pinniped species (California sea lion, Northern elephant seal and Ringed seal) were compared to several terrestrial species. Lavage samples were purified using a NaBr discontinuous gradient. Concentrations of phospholipid classes and molecular species were measured using electrospray… Expand
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References

SHOWING 1-10 OF 60 REFERENCES
The development of the pulmonary surfactant system in California sea lions.
TLDR
The composition and function of surfactant from newborn California sea lions suggest that this age group is similar to terrestrial newborn mammals, whereas the adult has a "diving mammal" surfactants that can aid the lung during deep dives. Expand
Surfactant from diving aquatic mammals.
TLDR
Analysis of surfactant in bronchoalveolar lavage fluid obtained from nine pinnipeds and from pigs and humans found a higher concentration of phospholipid and relatively more fluidic phosphatidylcholine molecular species, perhaps to facilitate rapid spreading during alveolar reexpansion. Expand
The surface activity of pulmonary surfactant from diving mammals
TLDR
It is suggested that reducing surface tension to very low values is not the primary function of surfactant in pinnipeds as it is in terrestrial mammals, but that an anti-adhesive surfactants is more important to enable the lungs to reopen following collapse during deep diving. Expand
A comparison of the molecular species compositions of mammalian lung surfactant phospholipids.
  • A. Postle, E. Heeley, D. Wilton
  • Chemistry, Medicine
  • Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
  • 2001
TLDR
It is concluded that this effectively monounsaturated composition of anionic phospholipid molecular species is a common characteristic of mammalian surfactants. Expand
Dipalmitoylphosphatidylcholine is not the major surfactant phospholipid species in all mammals.
  • C. Lang, A. Postle, +7 authors C. Daniels
  • Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2005
TLDR
There is no single PL molsp composition that functions optimally in all mammals; rather, surfactant from each animal is unique and tailored to the biology of that animal. Expand
The Changing State of Surfactant Lipids: New Insights from Ancient Animals
TLDR
Homology of the surfactant protein SP-A within the vertebrates points to a single evolutionaryorigin for the system and indicates that fish surfactants is a “protosurfactant”. Expand
The pattern of surfactant cholesterol during vertebrate evolution and development: does ontogeny recapitulate phylogeny?
TLDR
The uniformity of composition between species, despite differences in lung morphology, birthing strategy and relationship to each other, implies that the ratios are critical for the onset of pulmonary ventilation, which represents an example of ontogeny recapitulating phylogeny. Expand
Pivotal role of anionic phospholipids in determining dynamic behavior of lung surfactant.
TLDR
It is suggested that APLs play a critical role in promoting surface film stability during dynamic compression through interactions with nonlipid surfactant components, and prevent destabilization of the surface film by cholesterol and other NL. Expand
Periodic Fluctuations in the Pulmonary Surfactant System in Gould’s Wattled Bat (Chalinolobus gouldii)
TLDR
Cholesterol appears to function in maintaining surfactant fluidity during torpor in this species of bat, which is six times lower than in other mammals. Expand
Subfractionation of lung surfactant. Implications for metabolism and surface activity.
TLDR
The results suggest that subfractions of surfactant are extensively recycled in a metabolic sequence in which heavier, more dense material is a precursor to lighter, less dense material. Expand
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1
2
3
4
5
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