The composition of pulmonary surfactant from diving mammals

  title={The composition of pulmonary surfactant from diving mammals},
  author={Natalie J. Miller and Anthony D. Postle and Sandra Orgeig and Grielof Koster and Christopher Brian Daniels},
  journal={Respiratory Physiology \& Neurobiology},
Pulmonary surfactants and their role in pathophysiology of lung disorders.
The biochemical, physiological, developmental and clinical aspects of pulmonary surfactant are presented in this article to understand the pathophysiological mechanisms of these diseases.
Environmental Selection Pressures Shaping the Pulmonary Surfactant System of Adult and Developing Lungs
The major discoveries concerning how temperature, pressure and hypoxia have influenced the pulmonary surfactant system are summarised.
Evolution, Development, and Function of the Pulmonary Surfactant System in Normal and Perturbed Environments.
The evolutionary origin of the surfactant system, which likely predates lungs, is discussed and an analysis of the ontogeny of surfactants development among the vertebrates and the contribution of different regulatory mechanisms that control this development is presented.
Recent Advances into Understanding Some Aspects of the Structure and Function of Mammalian and Avian Lungs*
In the mammalian lung, dendritic cells of the pulmonary airways are powerful agents in engulfing deposited particles, and in birds, macrophages and erythrocytes are ardent phagocytizing cellular agents.
Respiratory function and mechanics in pinnipeds and cetaceans
Improved understanding of respiratory physiology under these conditions will be better able to define the physiological constraints imposed on these animals, and how these limitations may affect the survival of marine mammals in a changing environment.
Intrinsic anti-inflammatory properties in the serum of two species of deep-diving seal
The data suggest that seal serum possesses anti-inflammatory properties, which may protect deep divers from naturally occurring inflammatory challenges such as dive-induced hypoxia–reoxygenation and lung collapse.


The development of the pulmonary surfactant system in California sea lions.
Surfactant from diving aquatic mammals.
Analysis of surfactant in bronchoalveolar lavage fluid obtained from nine pinnipeds and from pigs and humans found a higher concentration of phospholipid and relatively more fluidic phosphatidylcholine molecular species, perhaps to facilitate rapid spreading during alveolar reexpansion.
A comparison of the molecular species compositions of mammalian lung surfactant phospholipids.
  • A. Postle, E. Heeley, D. Wilton
  • Biology, Chemistry
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
  • 2001
Dipalmitoylphosphatidylcholine is not the major surfactant phospholipid species in all mammals.
  • C. Lang, A. Postle, C. Daniels
  • Biology
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2005
There is no single PL molsp composition that functions optimally in all mammals; rather, surfactant from each animal is unique and tailored to the biology of that animal.
The Changing State of Surfactant Lipids: New Insights from Ancient Animals
Homology of the surfactant protein SP-A within the vertebrates points to a single evolutionaryorigin for the system and indicates that fish surfactants is a “protosurfactant”.
The pattern of surfactant cholesterol during vertebrate evolution and development: does ontogeny recapitulate phylogeny?
The uniformity of composition between species, despite differences in lung morphology, birthing strategy and relationship to each other, implies that the ratios are critical for the onset of pulmonary ventilation, which represents an example of ontogeny recapitulating phylogeny.
Pivotal role of anionic phospholipids in determining dynamic behavior of lung surfactant.
It is suggested that APLs play a critical role in promoting surface film stability during dynamic compression through interactions with nonlipid surfactant components, and prevent destabilization of the surface film by cholesterol and other NL.
Identification of phosphocholine plasmalogen as a lipid component in mammalian pulmonary surfactant using high-resolution 31P NMR spectroscopy.
High-resolution 31P NMR spectroscopy was used to analyze the phospholipid composition of mammalian pulmonary surfactant from two different sources and unequivocally demonstrate that a phosphocholine plasmalogen exists as a major secondary component in mammalian pulmonary Surfactant.