The composition of West Nile virus lipid envelope unveils a role of sphingolipid metabolism in flavivirus biogenesis.

@article{MartnAcebes2014TheCO,
  title={The composition of West Nile virus lipid envelope unveils a role of sphingolipid metabolism in flavivirus biogenesis.},
  author={Miguel A Mart{\'i}n-Acebes and Teresa Merino-Ramos and Ana B Bl{\'a}zquez and Josefina Casas and Estela Escribano-Romero and Francisco Sobrino and Juan-Carlos Saiz},
  journal={Journal of virology},
  year={2014},
  volume={88 20},
  pages={12041-54}
}
West Nile virus (WNV) is an emerging zoonotic mosquito-borne flavivirus responsible for outbreaks of febrile illness and meningoencephalitis. The replication of WNV takes place on virus-modified membranes from the endoplasmic reticulum of the host cell, and virions acquire their envelope by budding into this organelle. Consistent with this view, the cellular biology of this pathogen is intimately linked to modifications of the intracellular membranes, and the requirement for specific lipids… CONTINUE READING
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