The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs.

@article{Villac2004TheCO,
  title={The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs.},
  author={Patricia Villac{\'e} and Rosa Mar{\'i}a Mari{\'o}n and Juan Ort{\'i}n},
  journal={Nucleic acids research},
  year={2004},
  volume={32 8},
  pages={2411-20}
}
hStaufen is the human homolog of dmStaufen, a double-stranded (ds)RNA-binding protein involved in early development of the fly. hStaufen-containing complexes were purified by affinity chromatography from human cells transfected with a TAP-tagged hStaufen gene. These complexes showed a size >10 MDa. Untagged complexes with similar size were identified from differentiated human neuroblasts. The identity of proteins present in purified hStaufen complexes was determined by mass spectrometry and the… CONTINUE READING