The composite solubility versus pH profile and its role in intestinal absorption prediction

@article{Hendriksen2003TheCS,
  title={The composite solubility versus pH profile and its role in intestinal absorption prediction},
  author={Barry A. Hendriksen and Manuel V. Sanchez Felix and Michael B. Bolger},
  journal={AAPS PharmSci},
  year={2003},
  volume={5},
  pages={35-49}
}
The purpose of this study was to examine absorption of basic drugs as a function of the composite solubility curve and intestinally relevant pH by using a gastrointestinal tract (GIT) absorption simulation based on the advanced compartmental absorption and transit model. Absorption simulations were carried out for virtual monobasic drugs having a range of pKa, log D, and dose values as a function of presumed solubility and permeability. Results were normally expressed as the combination that… CONTINUE READING