The complexity of complexes in signal transduction

  title={The complexity of complexes in signal transduction},
  author={William S. Hlavacek and James R. Faeder and Michael L. Blinov and Alan S. Perelson and Byron Goldstein},
  journal={Biotechnology and Bioengineering},
Many activities of cells are controlled by cell‐surface receptors, which in response to ligands, trigger intracellular signaling reactions that elicit cellular responses. A hallmark of these signaling reactions is the reversible nucleation of multicomponent complexes, which typically begin to assemble when ligand‐receptor binding allows an enzyme, often a kinase, to create docking sites for signaling molecules through chemical modifications, such as tyrosine phosphorylation. One function of… 

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