The complexities of microRNA regulation: mirandering around the rules.

  title={The complexities of microRNA regulation: mirandering around the rules.},
  author={Kimberly Breving and Aurora Esquela-Kerscher},
  journal={The international journal of biochemistry & cell biology},
  volume={42 8},
MicroRNAs (miRNAs) are an important class of non-coding small RNAs that possess a large range of biological activities in a variety of organisms and are linked to human diseases such as cancer. Initially, miRNAs were thought to act solely as negative regulators of gene expression and exert their effects by binding to regions within the 3'UTR of their target protein-coding messenger RNAs (mRNAs) in a sequence dependent manner. However, recent data reveals that miRNA regulation entails a far more… CONTINUE READING
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