The complexes of mammalian target of rapamycin.

@article{Zhou2010TheCO,
  title={The complexes of mammalian target of rapamycin.},
  author={Hongyu Zhou and Shile Huang},
  journal={Current protein & peptide science},
  year={2010},
  volume={11 6},
  pages={
          409-24
        }
}
The mammalian target of rapamycin (mTOR) has attracted substantial attention because of its involvement in a variety of diseases, such as cancer, cardiac hypertrophy, diabetes and obesity. Current knowledge indicates that mTOR functions as two distinct multiprotein complexes, mTORC1 and mTORC2. mTORC1 phosphorylates p70 S6 kinase (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), and regulates cell growth, proliferation, and survival by integrating hormones, growth… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 61 CITATIONS

Overnutrition, mTOR signaling, and cardiovascular diseases.

  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2014
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

PKCε Increases Extracellular Elastin and Fibulin-5/DANCE in Dermal Fibroblasts.

  • Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
  • 2018

FILTER CITATIONS BY YEAR

2010
2019

CITATION STATISTICS

  • 5 Highly Influenced Citations

  • Averaged 4 Citations per year over the last 3 years

Similar Papers

Loading similar papers…