The complex whiJ locus mediates environmentally sensitive repression of development of Streptomyces coelicolor A3(2)

@article{Ansa2010TheCW,
  title={The complex whiJ locus mediates environmentally sensitive repression of development of Streptomyces coelicolor A3(2)},
  author={Jos{\'e} Antonio A{\'i}nsa and Nick P Bird and N. Jamie Ryding and Kim C. Findlay and Keith F. Chater},
  journal={Antonie van Leeuwenhoek},
  year={2010},
  volume={98},
  pages={225-236}
}
A segment of DNA was isolated that complemented several poorly characterised sporulation-defective white-colony mutants of Streptomyces coelicolor A3(2) from an early collection (Hopwood et al., J Gen Microbiol 61: 397–408, 1970). Complementation was attributable to a gene, SCO4543, named whiJ, encoding a likely DNA-binding protein. Surprisingly, although some mutations in whiJ had a white colony phenotype, complete deletion of the wild-type or mutant gene gave a wild-type morphology. The whiJ… CONTINUE READING
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