The complex that inserts lipopolysaccharide into the bacterial outer membrane forms a two-protein plug-and-barrel.

@article{Freinkman2011TheCT,
  title={The complex that inserts lipopolysaccharide into the bacterial outer membrane forms a two-protein plug-and-barrel.},
  author={Elizaveta Freinkman and S I Chng and Daniel E Kahne},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 6},
  pages={2486-91}
}
The cell surfaces of Gram-negative bacteria are composed of lipopolysaccharide (LPS). This glycolipid is found exclusively in the outer leaflet of the asymmetric outer membrane (OM), where it forms a barrier to the entry of toxic hydrophobic molecules into the cell. LPS typically contains six fatty acyl chains and up to several hundred sugar residues. It is biosynthesized in the cytosol and must then be transported across two membranes and an aqueous intermembrane space to the cell surface… CONTINUE READING

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