The complex role of multivalency in nanoparticles targeting the transferrin receptor for cancer therapies.

@article{Wang2010TheCR,
  title={The complex role of multivalency in nanoparticles targeting the transferrin receptor for cancer therapies.},
  author={Jin Wang and Shaomin Tian and Robby A. Petros and Mary E. Napier and Joseph M DeSimone},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 32},
  pages={11306-13}
}
Transferrin receptor (TfR, CD71) has long been a therapeutic target due to its overexpression in many malignant tissues. In this study, PRINT() nanoparticles were conjugated with TfR ligands for targeted drug delivery. Cylindrical poly(ethylene glycol)-based PRINT nanoparticles (diameter (d) = 200 nm, height (h) = 200 nm) labeled with transferrin receptor antibody (NP-OKT9) or human transferrin (NP-hTf) showed highly specific TfR-mediated uptake by all human tumor cell lines tested, relative to… CONTINUE READING
64 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 64 extracted citations

Similar Papers

Loading similar papers…