The complex process of GETting tail-anchored membrane proteins to the ER.

@article{Chartron2012TheCP,
  title={The complex process of GETting tail-anchored membrane proteins to the ER.},
  author={Justin William Chartron and William M Clemons and Christian Suloway},
  journal={Current opinion in structural biology},
  year={2012},
  volume={22 2},
  pages={217-24}
}
Biosynthesis of membrane proteins requires that hydrophobic transmembrane (TM) regions be shielded from the cytoplasm while being directed to the correct membrane. Tail-anchored (TA) membrane proteins, characterized by a single C-terminal TM, pose an additional level of complexity because they must be post-translationally targeted. In eukaryotes, the GET pathway shuttles TA-proteins to the endoplasmic reticulum. The key proteins required in yeast (Sgt2 and Get1-5) have been under extensive… CONTINUE READING

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